Pathogenesis and etiology of demyelinating diseases

a symposium organized by Edith Pette and O.Westphal

Publisher: Karger in Basel

Written in English
Published: Pages: 701 Downloads: 531
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Edition Notes

Additamentum ad International Archives of Allergy and Applied Immunology, vol.36.

Statementedited by Krystina Burdzy and P.Kallo s.
ContributionsPette, Edith., Westphal, O., Burdzy, Krystina., Kallo s, P.
The Physical Object
Paginationxi,701p. :
Number of Pages701
ID Numbers
Open LibraryOL14365577M

Comi G, et al. Treatment of chronic inflammatory demyelinating polyneuropathy. Ital J Neurol Sci. ; Gorson KC, et al. Chronic inflammatory demyelinating polyneuropathy: clinical features and response to treatment in 67 consecutive patients with and without a monoclonal gammopathy. Neurology. ; This well-illustrated textbook covers the full range of lung and pleural diseases from the pathologic standpoint. Both diseases of adults and pediatric lung diseases are presented. The book will serve as an excellent guide to the diagnosis of these diseases, but in addition it explains the disease mechanisms and etiology. 'Etiology and Pathogenesis of Periodontal Disease' represents a new concept in periodontology with its pronounced focus on understanding through knowledge rather than presenting the present valid answers. Connections between the diseases in the periodontium and general health are described in detail. Editor-In-Chief: C. Michael Gibson, M.S., M.D. Overview. Idiopathic Inflammatory Demyelinating Diseases (IIDDs), sometimes known as Borderline forms of multiple sclerosis, is a collection of multiple sclerosis variants, sometimes considered different diseases.. Historical Perspective Classification Pathophysiology Causes Differentiating Idiopathic inflammatory Demyelinating Diseases from .

The generally accepted pathologic criteria of a demyelinating disease are (1) destruction of the myelin sheaths of nerve fibers with relative sparing of the other elements of nervous tissue, i.e., of axons, nerve cells, and supporting structures, which are less affected; (2) infiltration of inflammatory cells, particularly in a perivenous distribution; (3) lesions that are primarily in white. Pathophysiology and Natural History. Despite the diverse array of medical disorders that cause peripheral neuropathies, peripheral nerves exhibit only a few distinct pathologic reactions to an insult or disease: wallerian degeneration, axonal degeneration, and segmental demyelination.

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Leibowitz. Pathogenesis and etiology of demyelinating diseases. A symposium organized by Edith Pette and O. Westphal. Edited by Krystina Burdzy and P.

Kallós. Get this from a library. Pathogenesis and etiology of demyelinating diseases. A symposium, (Local no.

[Edith Pette; Otto Westphal; Krystina Burdzy; Paul Kallós;]. All fights reserved /94/$ (94)E THE PATHOGENESIS OF DEMYELINATING DISEASE N.

SCOLDING,* J. ZAJICEK, N. WOOD and D. COMPSTON University of Cambridge Neurology Unit, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, U.K. CONTENTS I. Introduction Demyelinating disease in man Cited by: There has been significant progress in our understanding of the pathology and pathogenesis of central nervous system inflammatory demyelinating diseases.

Neuropathological studies have provided fundamental new insights into the pathogenesis of these disorders and have led to major advances in our understanding of multiple sclerosis (MS) heterogeneity, the substrate of irreversible progressive Cited by: Email your librarian or administrator to recommend adding this book to your organisation's collection.

Common Pitfalls in Multiple Sclerosis and CNS Demyelinating Diseases. Mark Keegan; Online ISBN: The pathophysiology, classification. Chronic inflammatory demyelinating polyneuropathy (CIDP) is a neurological disorder that causes progressive weakness and impaired sensory function in the legs and arms.

Symptoms often include tingling or numbness (first in the toes and fingers), weakness of the arms and legs, loss of deep tendon reflexes, fatigue, and abnormal sensations. Other symptoms may include pain, difficulty.

Etiology (consisting of two Greek terms for “origin” and “study of”) refers to the study of the causes of a mental or physical disease. As parts of the etiology of a respective disease, only causes that directly initiate the disease process (and therefore necessarily temporarily have to precede the onset of the disease) are considered as etiological factors.

Multiple Sclerosis. (Book Reviews: Pathogenesis and Etiology of Demyelinating Diseases. A symposium, Locarno, Switzerland, May-June ). You can write a book review and share your experiences. Other readers will always be interested in your opinion of the books you've read.

Whether you've loved the book or not, if you give your honest and detailed thoughts then people will find new books that are right for them. Measles virus, one of the most contagious of all human viruses, has been largely contained by the development and use of a vaccine that was introduced 50 years ago.

These two volumes were timed to honor the introduction of the vaccine and to record the enormous advancements made in understanding the molecular and cell biology, pathogenesis, and control of this infectious disease.

A demyelinating disease is any disease of the nervous system in which the myelin sheath of neurons is damaged. This damage impairs the conduction of signals in the affected nerves. In turn, the reduction in conduction ability causes deficiency in sensation, movement, cognition, or other functions depending on which nerves are involved.

ther conditions, such as brain ischaemia and intoxication. Irrespective of the primary aetiology, selective demyelination can be mediated through various pathogenetic pathways: the immune-mediated inflammatory pathway; the metabolic pathway; and the ischaemic/excitotoxic pathway.

These pathways are only partly segregated with distinct aetiologies of demyelinating diseases, but they also. TY - CHAP.

T1 - Infectious Demyelinating Diseases. AU - Johnson, Richard T. AU - Major, Eugene O. PY - /12/1. Y1 - /12/1. N2 - This chapter focuses on three human CNS demyelinating diseases-namely, acute disseminated encephalomyelitis (ADEM), also known as postinfectious encephalomyelitis, progressive multifocal leukoencephalopathy (PML), and multiple sclerosis (MS).

Title: Demyelinating Diseases 1 Demyelinating Diseases. By ; Dr. Amal Mokhtar, MD. Demylinating disease refers to a group of CNS disorders in which the primary pathology is demyelination without axonal degeneration. Multiple Sclerosis ; MS is a disease of unkown cause,in which discrete areas of demylination develop at many.

In virus-induced demyelination, infection is a necessary prerequisite for demyelination, and the cause/effect relationship makes this model an attractive platform for exploring the etiology and pathogenesis of demyelinating diseases.

Luciana Parente Costa Seguro, Sandra Gofinet Pasoto, in Infection and Autoimmunity (Second Edition), Multiple Sclerosis. The etiology of multiple sclerosis, an autoimmune disease of the central nervous system, is still unknown, but some risk factors have been implicated in its pathogenesis, including an association of genetic susceptibility and environmental agents.

CNS demyelination autoimmune disease causes the myelin sheath to deteriorate since the sense of recognition of self is lost. The loss of the myelin insulation either disrupts or prevents neural conduction along the nerve cell's axon.

The pathogenesis of the demyelination can vary. Some of the factors that contribute to the deteriorating of. It is clear that the etiology of many autoimmune diseases is influenced by both genetic and environmental factors.

This is certainly true for multiple sclerosis (MS), a T cell-mediated demyelinating disease of the central nervous system (CNS) characterized by autoimmune responses to myelin proteins such as myelin basic protein (MBP.

T1 - Pathology of demyelinating diseases. AU - Popescu, Bogdan AU - Lucchinetti, Claudia F. PY - /2/ Y1 - /2/ N2 - There has been significant progress in our understanding of the pathology and pathogenesis of central nervous system inflammatory demyelinating diseases.

Acute disseminated encephalomyelitis (ADEM) is an immune-mediated inflammatory demyelinating condition that predominately affects the white matter of the brain and spinal cord. The disorder manifests as an acute-onset encephalopathy associated with polyfocal neurologic deficits and is typically self-limiting.

Connective tissue diseases are characterized by different organ disorders due to loss of immune system tolerance to autoantigens. Peripheral neuropathy is one of the features of these diseases with variable frequency; it is more prevalent in Sjögren syndrome. Peripheral neuropathy is often seen in the course of the disease.

Nonetheless, it may be also a presenting sign or the unique. Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). Both genetic and environmental causes for MS have been suggested.

Recent genome-wide association studies revealed new susceptibility alleles for MS besides the HLA complex that are all relate. Animal Model for Viral- Induced Demyelinating Diseases. Mouse model studies using Theiler's murine encephalomyelitis virus (TMEV) [18, 19] infection and neurotropic strains of Mouse hepatitis virus (MHV) infection have given useful information on putative MS mechanisms [20–23].In virus-induced demyelination, infection is a necessary prerequisite for demyelination, and the cause/effect.

Cortical disease has emerged as a critical aspect of the pathogenesis of multiple sclerosis, being associated with disease progression and cognitive impairment.

viruses and demyelinating diseases Posted By Penny JordanPublishing TEXT ID bbab Online PDF Ebook Epub Library listings this is just one of the solutions for you to be successful as understood success does not suggest that you have wonderful points comprehending as skillfully as treaty even more than.

Guillain-Barre syndrome (GBS) is a reactive, self-limited, monophasic disease triggered by a preceding bacterial or viral infection. GBS has also been linked to underlying systemic diseases, certain malignancies, surgery, pregnancy, trauma severe infection.

This causes inflammation and injury to the sheath and ultimately to the nerve fibers that it surrounds. The process can result in multiple areas of scarring (sclerosis).

Other causes. Other types of demyelinating disease and their causes include: Optic neuritis — inflammation of the optic nerve in one or both eyes. “ Demyelinating” diseases Mark L Cohen, M.D.

Department of Pathology University Hospitals Case Medical Center January 6 th, Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising.

Demyelinating encephalitis is a type of encephalitis in which the insulating myelin sheath surrounding nerve fibers is damaged. Most types of demyelinating encephalitis are known to be caused by viral infection, and therefore the nature of viral persistence in the central nervous system (CNS) has become crucial to understanding the pathogenesis of associated diseases.

Merck & Co., Inc., Kenilworth, NJ, USA is a global healthcare leader working to help the world be well. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world.

The Merck Manual was first published in as a service to the community.Chronic inflammatory demyelinating polyneuropathy (CIDP) is a neurological disorder characterized by slowly progressive weakness and a loss of sensation in the legs and arms. CIDP is more common in young adults, and it affects men more than women.etiology - "The study of causes, as in the causes of a disease." Pathogenesis: "The development of a disease and the chain of events leading to that disease." So I decided to try wikipedia as, I felt, all definitions will necessarily fail to actually explain the differences .